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-72-PlanmecaRomexis0074 Lateral CephalometricAnalysis in Orthodontics Based on Magnetic Resonance ImagingOral Presentation8:45 AM–9:00 AM Mar 22, 2017CC, Room 3006 Authors:Alexander Heil(Presenter)Heidelberg University HospitalAlexander Heil(Presenter)Heidelberg University HospitalEduardo LazoGonzalez, Heidelberg University HospitalTim Hilgenfeld, Heidelberg University HospitalPhilipp Kickingereder, Heidelberg University HospitalAndreas Sommer, Heidelberg University HospitalMartin Bendszus, Heidelberg University HospitalSabine Heiland, Heidelberg University HospitalChristopher Lux, Heidelberg University HospitalSebastian Zingler, Heidelberg University HospitalSebastian Zingler, Heidelberg University HospitalAbstract: Objectives: The objective of this study was to evaluate whether magnetic resonance imaging (MRI) can serve as a non-ionizing alternative to lateral cephalometricradiographs (LCR) in cephalometricanalysis.Methods: This prospective study was approved by the local research ethics committee, informed patient consent was obtained. The applied MRI technique was optimized for detection of cephalometriclandmarks and geometric accuracy. Prior to orthodontic treatment, 20 patients (mean age ±SD, 13.95 years ±5.34; 8 females) received MRI and LCR. MRI datasets were (mean age ±SD, 13.95 years ±5.34; 8 females) received MRI and LCR. MRI datasets were postprocessedinto lateral cephalograms(AMIRA-3D v5.4.1). Based on 10 midsagittaland 9 bilateral landmarks 24 widely used cephalometricmeasurements (14 angles, 10 distances) were taken twice by two observers for both modalities (PlanmecaRomexisv4.4.0). Statistical analysis was performed by using intraclasscorrelation coefficient (ICC), Bland-Altman analysis and two one-sided tests (TOST) with an equivalence margin of ±2 °/mm.Results: Geometric accuracy of the MRI technique was confirmed. Mean intraobserverICC were 0.977/0.975 for MRI and 0.975/0.961 for LCR. Average interobserverICC were 0.980 for MRI and 0.929 for LCR. Bland-Altman analysis showed high of levels agreement between the two modalities, bias range (mean ±SD) was -0.66 to 0.61 mm (0.06 ±0.44) for distances and -modalities, bias range (mean ±SD) was -0.66 to 0.61 mm (0.06 ±0.44) for distances and -1.33 to 1.14 °(0.06 ±0.71) for angles. Except for the interincisalangle (P= .17) all measurements were statistically equivalent (P < .05).Conclusions: MRI datasets can be transformed into lateral cephalogramsallowing reliable measurements as applied in orthodontic routine with high levels of agreement to the corresponding measurements performed on LCR. Thus, MRI-based orthodontic treatment planning appears feasible.Image(s):This abstract is based on research that was funded entirely or partially by an outside source:DietmarHoppFoundation, grant number 23011228Disclosure Statement:The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The Reprinted with permission from the Journal of Dental Research, J Dent Res 96 (Spec Iss A):-72-relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: Alexander Heil, Sabine Heiland, Christopher Luxand Sebastian Zinglerreceive a grant from the DietmarHoppFoundation (project number 23011228).I have read the IADR policy on licensing.Signed by Alexander Heilabstract number 0074, https://iadr2017.zerista.com/event/member/329785, 2017