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-68-Carbonated apatite granule2845 In vivo Evaluation of Carbonate Apatite in Canine Peri-implant ModelPoster Presentation3:45 PM–5:00 PM Mar 24, 2017CC, First Floor Authors:Authors:Yusuke Shigemitsu (Presenter)GC CorporationKatsuyukiYamanaka, GC CorporationShinichi Kato, GC CorporationKatsushi Yamamoto, GC CorporationHijiriMasuda, GC CorporationYoko Ishihara, GC CorporationHidetoshi Funabashi, GC CorporationHidetoshi Funabashi, GC CorporationTomohiro Kumagai, GC CorporationAbstract: Objectives: Although the gold standard for bone defect reconstruction is autograft, it has serious limitations including the operation to healthy site and insufficient availability. Xenograftalso has limitations including potential infection risks. To solve these problems, we focused on synthetic carbonated apatite (CO3Ap). In this study, we aimed to evaluate the effect of bone regeneration carbonated apatite (CO3Ap). In this study, we aimed to evaluate the effect of bone regeneration using CO3Ap in peri-implant bone defect model in canine.Methods: CO3Ap granules was fabricated by compositional transformation based on dissolution precipitation reaction using microporouslow crystalline calcite granules as a precursor. The animal experiments were performed at HamriCo., Ltd., which has been approved by the AAALAC International. 4 adult beagle dogs were used. Implant placement and peri-implant bone regeneration were performed 2 months after tooth extraction in the mandible. 2 standardized 5×5×4 mm box-shaped defects with a dehiscence of 5 mm were bilaterally created, and Φ3.8 mm dental implants were placed in distal of the defects. 4 bone graft materials were randomly mm dental implants were placed in distal of the defects. 4 bone graft materials were randomly applied: i) CO3Ap, ii) NEOBONE®, iii) Bio-Oss®, iv) Cerasorb® M. After healing period of 12 weeks, micro-CT and histological evaluation were performed.Results: There were no differences in mineralized tissue area including bone graft materials from micro-CT image among all groups. Histological evaluation with Villanueva Goldnerstaining revealed a relatively higher augmented area for CO3Ap groups compared to others. Regarding the bone-to-implant contact, CO3Ap was superior to all other groups at 12 weeks.Conclusions: CO3Ap possess the ability to form new bone tissue on dog mandibularbone, which shows the potential of using this material to generate bone and repair the peri-implant bone shows the potential of using this material to generate bone and repair the peri-implant bone defect clinically.Disclosure Statement:The submitter must disclose the names of the organizations with which any author have a relationship, the nature of the relationship, and the clinical or research area involved. The following is submitted: NONEI have read the IADR policy on licensing.Signed by Yusuke ShigemitsuReprinted with permission from the Journal of Dental Research, J Dent Res 96 (Spec Iss A):-68-abstract number 2845, https://iadr2017.zerista.com/event/member/331814, 2017