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-49-Phosphopullulan1712 Keynote Address: Therapeutic Innovation Derived from Basic Research of Dental MaterialsOral Presentation8:00 AM–8:30 AM Mar 24, 2017CC, Room 2020 Authors:Authors:Yasuhiro Yoshida (Presenter)Hokkaido UniversityAbstract: Abstract Body: A biodegradable material that bonds to hard tissues such as bones and teeth is urgently needed for medical and dental applications in both tissue engineering and regenerative medicine. We developed a novel hard-tissue bioadhesiveusing biodegradable phosphopullulan. The polysaccharide ‘pullulan’ was chemically functionalized with dihydrogenphosphopullulan. The polysaccharide ‘pullulan’ was chemically functionalized with dihydrogenphosphate groups to chemically bridge the biomaterial with the hard tissue via ionic binding of the phosphate functional groups to the calcium in apatite. Phosphopullulanbioadhesiveshows a higher bond strength to apatite and titanium compared to polymethylmethacrylateand calcium phosphate cements. Our results reveal sufficient bone/dentin adaptation and inducible regeneration processes, which enable stable mechanical and functional repair of bone and tooth defects. Furthermore, phosphopullulanbioadhesivesmay be useful as a new drug delivery system. Phosphopullulanexhibited a controllable release pattern, which represents a unique drug release property. We are now developing two commercially represents a unique drug release property. We are now developing two commercially available dental products for pulp capping and root canal therapies.Reprinted with permission from the Journal of Dental Research, J Dent Res 96 (Spec Iss A):-49-abstract number 1712, https://iadr2017.zerista.com/event/member/329668, 2017